In 1998, the Vancouver Area Network of Drug Users (VANDU) emerged in response to the escalating drug crisis in Vancouver, specifically within the Downtown Eastside, aiming to provide a platform for individuals directly affected by addiction and punitive drug policies to organize. Advocating for harm reduction strategies, access to clean needles and the destigmatization of addiction, VANDU sought to transform the prevailing discourse. The founding of VANDU resulted in significant shifts in Vancouver’s approach to drug-related issues, prioritizing a health-based perspective over a criminal one and paving the way for more compassionate policies. Notably, VANDU’s advocacy played a pivotal role in establishing Insite, North America’s first supervised injection site, showcasing the effectiveness of harm reduction in preventing disease transmission and saving lives. VANDU’s inception acted as a catalyst, inspiring similar movements worldwide and highlighting the transformative power of community-driven efforts in addressing complex societal challenges.